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Author Topic: Short term effects of Chloroquine on the histology of the Sprague-Dawley Rats...  (Read 2806 times)
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Francis Umeoguaju
Expert in Bioscience Issues
Posts: 657

« on: October 16, 2012, 02:48:13 am »

Short term effects of Chloroquine on the histology of the Sprague-Dawley Rats Spleen

Akinribido F.A ,Okanlawon O.A, Yama O.E
Dept  Department of Biological Sciences, Bells University of Technology Ota, Ogun State
Dept Of Anatomy,College of Medicine, University of Lagos, Idi-Araba, Lagos State
(Research Work)
Correspondence to: Akinribido F.A,; +2348023654975


Significant binding of chloroquine occurs in the liver, kidney and spleen (Taylor and Francis 1987). For a very short period of three days, ten male rats were exposed to chloroquine phosphate injection intraperitoneally /IP) for three days. The treated rats received 0.125ml/100g body weight of chloroquine phosphate injection intraperitoneally. Control rats received the same amount of normal saline intraperitoneally. Histologically, the micrographs of control and treated rats spleen were compared. Investigations confirmed defects in microscopic structures. In the spleen there were few white pulps in the treated rats compared with controls with controls.

Keywords:chloroquine, spleen, sprague-dawley rats, histology.

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