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Author Topic: Short term effects of chloroquine on the stereology of rats brain  (Read 2429 times)
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Francis Umeoguaju
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« on: March 04, 2012, 10:54:43 am »


Short term effects of chloroquine on the stereology of Sprague –Dawley rats brain (cerebral cortex)


Akinribido F.A ,Okanlawon O.A, Yama O.E
Dept  Department of Biological Sciences, Bells University of Technology Ota, Ogun State
Dept Of Anatomy,College of Medicine, University of Lagos, Idi-Araba, Lagos State
(Research Work)
Correspondence to: Akinribido F.A, fumibos@yahoo.co.uk; +2348023654975

ABSTRACT

Chloroquine had been reported to cause retinopathy, cochlea vestibular dysfunction these are being controlled by the brain. It is therefore necessary to study its effects on the brain (Taylor and Francis 1987). For a very short period of three days, ten male rats were exposed to chloroquine phosphate injection intraperitoneally /IP) for three days. The treated rats received 0.125ml/100g body weight of chloroquine phosphate injection intraperitoneally. Control rats received the same amount of normal saline intraperitoneally. Stereologically, the estimated absolute volume V=VV(structure) x V(ref) of pyramidal cells was determined and compared. Chloroquine caused a reduction in the absolute volume of treated brain pyramidal cells compared with controls.

Keywords:  Chloroquine, Sprague-Dawley rats, brain (cerebral cortex),stereology.
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