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Author Topic: Short term effects of chloroquine on the stereology of the heart muscle of rats  (Read 2231 times)
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Francis Umeoguaju
Expert in Bioscience Issues
Posts: 657

« on: March 04, 2012, 11:02:36 am »

Short term effects of chloroquine on the stereology of the heart muscle of Sprague dawley rats

Akinribido F.A ,Okanlawon O.A, Yama O.E
Dept  Department of Biological Sciences, Bells University of Technology Ota, Ogun State
Dept Of Anatomy,College of Medicine, University of Lagos, Idi-Araba, Lagos State
(Research Work)
Correspondence to: Akinribido F.A,; +2348023654975


Chloroquine had been reported to cause retinopathy, cochlea vestibular dysfunction these are being controlled by the brain. It is therefore necessary to study its effects on the brain (Taylor and Francis 1987).Hence this study was designed to determine the histomorphometric effects of administration of chloroquine on the brain. Ten male rats were exposed to chloroquine (intraperitoneally/IP) for three days. The treated rats received  0.125/100g body weight of chloroquine phosphate injection intraperitoneally. Control rats received the same amount of normal saline intraperitoneally. The histology of the chloroquine treated rats brain was compared with controls, there were few pyramidal cells and martinotti cells in the treated rats compared with controls. It was observed that chloroquine caused shrinkages and contrition in the pyramidal cells of the brain (cerebral cortex) and cells of martinotti of the cerebral cortex. Stereologically, the estimated absolute volume V=VV(structure) x V(ref) of pyramidal cells was determined and compared. Chloroquine caused a reduction in the absolute volume oftreated brain pyramidal cells compared with controls.

Keywords:   Chloroquine, Sprague-Dawley rats, brain (cerebral cortex), histology, stereology.

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