Short term effects of Chloroquine on the stereology of the Sprague-Dawley Rats Spleen
Akinribido F.A ,Okanlawon O.A, Yama O.E (2012)
Dept Department of Biological Sciences, Bells University of Technology Ota, Ogun State
Dept Of Anatomy,College of Medicine, University of Lagos, Idi-Araba, Lagos State
(Research Work)
Correspondence to: Akinribido F.A, fumibos@yahoo.co.uk; +2348023654975
ABSTRACT
Significant binding of chloroquine occurs in the liver, kidney and spleen (Taylor and Francis 1987).
For a very short period of three days, ten male rats were exposed to chloroquine phosphate injection intraperitoneally /IP) for three days. The treated rats received 0.125ml/100g body weight of chloroquine phosphate injection intraperitoneally. Control rats received the same amount of normal saline intraperitoneally.
Stereologically, the parameters measured for the spleen was compared with controls. The estimated absolute volume V =Vv (structure) x v (ref) of the white pulps of the fractions was determined and compared. In the spleen chloroquine caused a reduction in the absolute volume of the white pulp when compared with controls.
Keywords: chloroquine, spleen, sprague-dawley rats, stereology.
Author