|
|
|
|
|
|
Sponsored links
Sponsored links
Search Tags |
|
|
|
An online informational and educational resourceful center for all Nigerian Bioscientists |
|
|
Anouncements
Enable Javascript to view contents
Featured Posts
Enable Javascript to view contents |
|
The Effects of Chloroquine on the Morphology and Stereology of the Sprague-Dawley Rats Liver, Kidney and Spleen
|
Akinribido* F.A, Noronha* C.C and Okanlawon* O.A (2011) |
Dept of Anatomy and Biochemistry, Bells University of technology Ota, Ogun State (Research Work) |
Correspondence to: Akinribido F.A, fumibos@yahoo.co.uk; +2348023654975 |
|
Abstract |
Significant binding of chloroquine occurs in the liver, kidney and spleen (Taylor and Francis 1987).Hence this study was designed to determine the effects of administration of chloroquine on the morphology and stereology of the liver, kidney and spleen. Ten rats were exposed to chloroquine once a day for three days. The treated rats received the 0.125ml/100g body weight of chloroquine phosphate injection intraperitineally.Control rats received the same amount of normal saline intraperitoneally .the histology of the chloroquine treated kidney, liver and spleen was also compared with controls. It was observed that chloroquine caused malformation in these tissues. Histologically, the micrographs of control and treated rats, liver, kidney and spleen was compared. Investigations confirmed defects in microscopic structures e.g. for the kidney there were few renal corpuscles in the treated rats compared with controls. For the liver there were few blood vessels in the treated rats compared with controls. For the spleen there were few white pulps in the treated rats compared with controls with controls. Stereologically, the parameters measured for kidney, liver and spleen was also compared with controls. The estimated absolute volume V =Vv (structure) x v (ref) of the blood vessels, renal corpuscles and white pulps of the fractions were determined and compared. For the liver chloroquine caused a reduction in the absolute volume of the blood vessels when compared with controls. For the kidney, chloroquine caused a reduction in the absolute volume of the white pulps when compared with control rats
|
Keywords: chloroquine, liver, kidney, spleen, sprague-dawley rats, stereology, morphology |
|
|
|
|
|
|
" Recent life science news and headlines" is a one stop science news group and free monthly e-newsletter for both scientists and non scientist. We actively scan through some of the world most current and reliable science news sites to bring you interesting and newsworthy bioscience, medical, general science and research findings headline collections. So, you can now always be the first to get that news/story. Subscribing to Recent life science news and headlines ensures that you have our free monthly e-news collections delivered right into your email box.You can access our most current e-news collections HERE. |
|
|
QUICK LINK
Nigerian Bioscientists interactive forum and Online community:::
|
|
|
Your opinions, questions and contributions counts, to creating a better online community. |
Information and News on Nigerian Bioscientists related issues:::
|
|
|
|
EXCERPTS FROM FORUM DISCUSSIONS
Most recent forum posts:::
Loading Javascript contents....
You need to enable the javascript of your brower to view this content.
|
|
|
|
Has this site been of any use to you? You can help us by informing other Nigerian Bioscientists and indeed all bioscientist about us. You can also help us to serve you better! . Thanks for visiting nigerianbioscientist.com! |
|
|
Are you a Nigerian Scientist?, We are out to meet your Bioscience needs.
Join Us today & Let your voice be heard!
Register?
Login?
ROW CALL.
Join us in welcoming newly Registered Nigerian Bioscientist.
Click Here
Loading Javascript contents....
You need to enable the javascript of your brower to view this content.
|
What you stand to gain by being a member.
> International Recognitions,
>Assistance to research and academic challenges,
>Nigerian Science Jobs, Latest Nigerian & world Bioscience news information,
>
online science community,
>and lots of other free science resources.
|
|
|